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The main goal of this research was to detennine effects of a submaxiamal aerobic exercise on rate of changes of ferritin, iron and TIBC blood plasma in
young patients with Talassemia Major. Standard Balke test was used on a treadmil that consisted of 25 stages and in order to be aware of risks involved during exercise, electrocardiogram leads were placed on subjects. Blood samples
were collected and analyzed in three stages, before, immediately after and 36 hours after test. Ten patients with Thalassemia Major were selected randomly and tested. Data were analyzed using statistical methods such as paired T- Test and Multi-regression. The results indicate: 1) the amount of ferritin decreased significantly during exercise compared with rest stage. 2) The amount of ferritin
in recovery period increased compared with exercise stage. 3) Iron and TIBC were not changed in either exercise or rest stage. 4) There was a positive correlation between ferritin, iron and TIBC recovery (r = 0.74). 5) Ferritin decreased below 65% HR.R, but increased above this level.