The aim of this investigation was to study the relationship between physical activity and cardiovascular risk factors in male managers of Shahid Chamran University. Subjects of the study consist of 89 managers and 168 non-managers aged between 25 and 66. Volunteer managers were also divided into physically active and physically unactive groups. A number of cardiovascular risk factors such as C-T, HDL-C, LDL- VLDL-C, TG,RF, HR, G,BP1,, BP2, %Fat and BMI were measured and analyzed by descriptive and inferential statistics at a = 0.05. The findings of this study showed that . There was a significant difference between C- T(a =0. 008),LDL-C (a = 0.012), VLDL-C(a =0.021), TG(a=0.001), FR(a=0.001) and %Fat(a=0.002) in managers and non-managers. There was no significant difference in other factors. Data also showed that the amount of C- T(a =0. 026),LDL-C (a0. 046), VLDL-C(a =0.005), TG(a=0.007), RF(a=0.018) and resting HR(a=0.014) in active managers were significantly lower than unactive managers, and in other related factors, there was no significant difference. The findings of the study suggests that managers should take part in regular physical activities in order to decrease and prevent the effects of cardiovascular risk factors.